Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus.

doi:10.1016/j.jgg.2025.11.003

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Article

Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus.

Journal of genetics and genomics = Yi chuan xue bao - 1 Apr 2026

Yu Hong-Ping, Xiang Bang-De, Qian Ji, Liu Hongliang, Li Yuan-Feng, Lin Qiuling, Liu Shun, Wei Junjie, Zhan Shicheng, Jiang Binbin, Dai Juncheng, Ma Liang, Zhang Litu, Liu Yingchun, Wen Qiuping, Gong Wenfeng, Li Shengping, Jiang Yanji, Zheng Ji, Zhu Tianyi, Zhou Zihan, Zeng Xiaoyun, Wang Ziliang, Wang Ji-Ao, Guo Rui, Yang Yuan, Wei Qingyi, Zhou Gangqiao, Qiu Xiao-Qiang, Tang Weizhong, Wang Mengyun, Zhang Ruoxin

Abstract excerpt

Liver cancer ranks sixth in cancer incidence and third in cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the primary histological subtype, and hepatitis B virus (HBV) carriers have a higher risk of HCC. Although several susceptibility loci for HCC have been identified in East Asian populations through genome-wide association studies (GWAS), the underlying biological mechanisms of this...

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Identifiers

PMID: 41241147
DOI: 10.1016/j.jgg.2025.11.003

Genes

FAM114A1
FOXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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