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Article

MYC drives overexpression of telomerase RNA ( hTR / TERC ) in prostate cancer

9 Sept 2017

Abstract excerpt

Telomerase consists of at least two essential elements, an RNA component hTR or TERC that contains the template for telomere DNA addition and a catalytic reverse transcriptase (TERT). While expression of TERT has been considered the key rate-limiting component for telomerase activity, increasing evidence suggests an important role for the regulation of TERC in telomere maintenance and perhaps other functions in...

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Share to Circular RNAs in diseases
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28888037
DOI: 10.1002/path.4980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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MYC drives overexpression of telomerase RNA ( hTR / TERC ) in prostate cancerPMID 28888037Read ↗

htert expression correlates with MYC over-expression in human prostate cancerSemantic proximity Read ↗

htert expression correlates withMYC over-expression in human prostate cancerSemantic proximity Read ↗

Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expressionSemantic proximity Read ↗

Functional Loss of ATRX and TERC Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer CellsSemantic proximity Read ↗

Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYCSemantic proximity Read ↗

hTERT, hTR and TERT promoter mutations as markers for urological cancers detection: A systematic review.Semantic proximity Read ↗

Immortalization of Primary Human Prostate Epithelial Cells by c-MycSemantic proximity Read ↗

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targetsSemantic proximity Read ↗

The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.Semantic proximity Read ↗

Prostate tumor cells with cancer progenitor properties have high telomerase activity and are rapidly killed by telomerase interferenceSemantic proximity Read ↗

TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERTSemantic proximity Read ↗

TERT-mediated induction of MIR500A contributes to tumor invasiveness by targeting Hedgehog pathwaySemantic proximity Read ↗

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