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Immortalization of Primary Human Prostate Epithelial Cells by c-Myc

15 Mar 2005

Abstract excerpt

A significant percentage of prostate tumors have amplifications of the c-Myc gene, but the precise role of c-Myc in prostate cancer is not fully understood. Immortalization of human epithelial cells involves both inactivation of the Rb/p16INK4a pathway and telomere maintenance, and it has been recapitulated in culture by expression of the catalytic subunit of telomerase, hTERT, in combination with viral...

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PMID: 15781629
DOI: 10.1158/0008-5472.can-03-4030

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