Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression

Abstract excerpt

Transcriptional reactivation of telomerase reverse transcriptase (TERT) reconstitutes telomerase activity in the majority of human cancers. Here, we found that ectopic TERT expression increases cell proliferation, while acute reductions in TERT levels lead to a dramatic loss of proliferation without any change in telomere length, suggesting that the effects of TERT could be telomere independent. We observed that...

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• Share to Advanced biosensing and bioanalysis techniques
• Share to RNA Interference and Gene Delivery
• Share to Telomeres, Telomerase, and Senescence