Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT

3 May 2024

Abstract excerpt

The core of telomerase consists of the protein subunit telomerase reverse transcriptase (TERT) and the telomerase RNA component (TERC). So far, the role of TERC in cancer development has remained elusive. Here, we found TERC expression elevated in non-small cell lung cancer (NSCLC) tissues, which was associated with disease progression and poor prognosis in patients. Using NSCLC cell lines and xenograft models,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular RNAs in diseases
Share to Nuclear Structure and Function
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38799568
DOI: 10.1016/j.isci.2024.109869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERTPMID 38799568Read ↗

Tumorigenic effect of TERT and its potential therapeutic target in NSCLC (Review).Semantic proximity Read ↗

Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complexSemantic proximity Read ↗

Telomerase deficiency and dysfunctional telomeres in the lung tumor microenvironment impair tumor progression in NSCLC mouse models and patient-derived xenograftsSemantic proximity Read ↗

Noncanonical functions of telomerase and telomeres in viruses‐associated cancerSemantic proximity Read ↗

TERC promotes cellular inflammatory response independent of telomeraseSemantic proximity Read ↗

The regulations of telomerase reverse transcriptase (TERT) in cancerSemantic proximity Read ↗

Telomerase RNA component lncRNA as potential diagnostic biomarker promotes CRC cellular migration and apoptosis evasion via modulation of β-catenin protein levelSemantic proximity Read ↗

Extratelomeric Functions of TelomeraseSemantic proximity Read ↗

RYBP Inhibits Progression and Metastasis of Lung Cancer by Suppressing EGFR Signaling and Epithelial-Mesenchymal TransitionSemantic proximity Read ↗

TERT Polymorphism rs2736100-C Is Associated with EGFR Mutation-Positive Non-Small Cell Lung Cancer.Semantic proximity Read ↗

Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypesSemantic proximity Read ↗

Circular RNA Circ_0016760 Modulates Non-Small-Cell Lung Cancer Growth Through the miR-577/ZBTB7A AxisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.