Article
TERT-mediated induction of MIR500A contributes to tumor invasiveness by targeting Hedgehog pathway
2020-02-19
Abstract excerpt
The classical activity of telomerase (TERT) is to maintain telomere homeostasis, ensuring chromosome stability and cellular proliferation. However, increasing evidences of telomere-independent human TERT functions have been lastly obtained. We report here that TERT directly binds to the TCF binding elements (TBE) located upstream the oncomiR MIR500A inducing its expression and promoting cancer invasiveness. This...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- efa28366-7553-5895-a5b8-3ba043198241
- DOI
- 10.1101/2020.02.18.954370