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Prostate tumor cells with cancer progenitor properties have high telomerase activity and are rapidly killed by telomerase interference

14 Feb 2011

Abstract excerpt

BACKGROUND: Cancer progenitor cells (CPCs) have been postulated to promote treatment resistance and disease progression in prostate and other malignancies. We investigated whether the enzyme telomerase, which is active in cancer cells and in normal stem cells, plays an important role in CPC which can be exploited to neutralize these cells. METHODS: We used flow cytometry and assays of gene expression,...

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PMID: 21321978
DOI: 10.1002/pros.21355

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