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Article

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

13 May 2022

Abstract excerpt

c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression. Although MYC is overexpressed in both early and metastatic disease and associated with poor survival, its impact on prostate transcriptional reprogramming remains elusive. We demonstrate that MYC overexpression significantly diminishes the androgen receptor (AR) transcriptional program (the set of genes directly targeted by the AR...

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PMID: 35562350
DOI: 10.1038/s41467-022-30257-z

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