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Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC

26 Jan 2017

Abstract excerpt

Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase activity primarily due to transcriptional repression of telomerase reverse transcriptase (TERT), the catalytic component of telomerase. Transcription factor binding, chromatin status as well as epigenetic modifications at the TERT...

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Identifiers

PMID: 28184371
DOI: 10.3389/fcell.2017.00001

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