Article
Genomic characterization of chromosome translocations in patients with T/myeloid mixed-phenotype acute leukemia.
Leukemia & lymphoma - 1 May 2018
Pallavajjala Aparna, Kim Daehwan, Li Tongbin, Ghiaur Gabriel, Jones Richard J, Burns Kathleen H, Salzberg Steven L, Ning Yi
Abstract excerpt
Mixed-phenotype acute leukemia (MPAL) is a progenitor type of leukemia with ambiguous expression of lineage markers. The diagnosis of MPAL is based on flow cytometric analysis of immunophenotype, which commonly identifies myeloid lineage markers as well as B- or T- lymphoid lineage markers on leukemic blasts. Due to the rare occurrence of this disease, few studies have delineated the molecular bases of MPAL....
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