Article
Single-cell RNA sequencing distinctly characterizes the wide heterogeneity in pediatric mixed phenotype acute leukemia.
Genome medicine - 16 Oct 2023
Mumme Hope L, Raikar Sunil S, Bhasin Swati S, Thomas Beena E, Lawrence Taylor, Weinzierl Elizabeth P, Pang Yakun, DeRyckere Deborah, Gawad Chuck, Wechsler Daniel S, Porter Christopher C, Castellino Sharon M, Graham Douglas K, Bhasin Manoj
Abstract excerpt
BACKGROUND: Mixed phenotype acute leukemia (MPAL), a rare subgroup of leukemia characterized by blast cells with myeloid and lymphoid lineage features, is difficult to diagnose and treat. A better characterization of MPAL is essential to understand the subtype heterogeneity and how it compares with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Therefore, we performed single-cell RNA...
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