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Article

Multiomic single cell sequencing identifies stemlike nature of mixed phenotype acute leukemia.

Nature communications - 18 Sept 2024

Peretz Cheryl A C, Kennedy Vanessa E, Walia Anushka, Delley Cyrille L, Koh Andrew, Tran Elaine, Clark Iain C, Hayford Corey E, D'Amato Chris, Xue Yi, Fontanez Kristina M, May-Zhang Aaron A, Smithers Trinity, Agam Yigal, Wang Qian, Dai Hai-Ping, Roy Ritu, Logan Aaron C, Perl Alexander E, Abate Adam, Olshen Adam, Smith Catherine C

Abstract excerpt

Despite recent work linking mixed phenotype acute leukemia (MPAL) to certain genetic lesions, specific driver mutations remain undefined for a significant proportion of patients and no genetic subtype is predictive of clinical outcomes. Moreover, therapeutic strategy for MPAL remains unclear, and prognosis is overall poor. We performed multiomic single cell profiling of 14 newly diagnosed adult MPAL patients to...

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Share to Gene Expression Profiling
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunophenotyping

Share to Neoplastic Stem Cells

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Source

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Identifiers

PMID: 39294124
DOI: 10.1038/s41467-024-52317-2
PMCID: PMC11411136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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