Article
Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes.
Experimental hematology - 1 Aug 2016
Eckstein Olive S, Wang Linghua, Punia Jyotinder N, Kornblau Steven M, Andreeff Michael, Wheeler David A, Goodell Margaret A, Rau Rachel E
Abstract excerpt
Mixed-phenotype acute leukemia (MPAL) is a heterogeneous group of poor-prognosis leukemias with immunophenotypic features of at least two cell lineages. The full spectrum of genetic mutations in this rare disease has not been elucidated, limiting our understanding of disease pathogenesis and our ability to devise targeted therapeutic strategies. Here, we sought to define the mutational landscape of MPAL by...
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