Article
Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes.
Nature communications - 10 Jul 2018
Takahashi Koichi, Wang Feng, Morita Kiyomi, Yan Yuanqing, Hu Peter, Zhao Pei, Zhar Abdallah Abou, Wu Chang Jiun, Gumbs Curtis, Little Latasha, Tippen Samantha, Thornton Rebecca, Coyle Marcus, Mendoza Marisela, Thompson Erika, Zhang Jianhua, DiNardo Courtney D, Jain Nitin, Ravandi Farhad, Cortes Jorge E, Garcia-Manero Guillermo, Kornblau Steven, Andreeff Michael, Jabbour Elias, Bueso-Ramos Carlos, Takaori-Kondo Akifumi, Konopleva Marina, Patel Keyur, Kantarjian Hagop, Futreal P Andrew
Abstract excerpt
Mixed phenotype acute leukemia (MPAL) is a rare subtype of acute leukemia characterized by leukemic blasts presenting myeloid and lymphoid markers. Here we report data from integrated genomic analysis on 31 MPAL samples and compare molecular profiling with that from acute myeloid leukemia (AML), B cell acute lymphoblastic leukemia (B-ALL), and T cell acute lymphoblastic leukemia (T-ALL). Consistent with the mixed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.