Integrative genomic and transcriptomic profiling reveals distinct molecular subsets in adult mixed phenotype acute leukemia.

doi:10.1002/ajh.26758

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Article

Integrative genomic and transcriptomic profiling reveals distinct molecular subsets in adult mixed phenotype acute leukemia.

American journal of hematology - 1 Jan 2023

Wang Qian, Cai Wen-Zhi, Wang Qin-Rong, Zhu Ming-Qing, Yan Ling-Zhi, Yu Yan, Bao Xie-Bing, Shen Hong-Jie, Yao Hong, Xie Jun-Dan, Zhang Tong-Tong, Zhang Ling, Xu Xiao-Yu, Shan Zhe, Liu Hong, Cen Jian-Nong, Liu Dan-Dan, Pan Jin-Lan, Lu Da-Ru, Chen Jia, Xu Yang, Zhang Ri, Wang Ying, Xue Sheng-Li, Miao Miao, Han Yue, Tang Xiao-Wen, Qiu Hui-Ying, Sun Ai-Ning, Huang Jin-Yan, Dai Hai-Ping, Wu De-Pei, Chen Su-Ning

Abstract excerpt

Mixed phenotype acute leukemia (MPAL) is a subtype of leukemia in which lymphoid and myeloid markers are co-expressed. Knowledge regarding the genetic features of MPAL is lacking due to its rarity and heterogeneity. Here, we applied an integrated genomic and transcriptomic approach to explore the molecular characteristics of 176 adult patients with MPAL, including 86 patients with T-lymphoid/myeloid MPAL (T/My...

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PMID: 36219502
DOI: 10.1002/ajh.26758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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