Article
Swapping of transmembrane domains in the epithelial calcium channel TRPV6.
Scientific reports - 6 Sept 2017
Singh Appu K, Saotome Kei, Sobolevsky Alexander I
Abstract excerpt
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its...
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