Article

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

2017-05-24

Abstract excerpt

Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo , affecting its...

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Literature Corpus work: 0a640154-d149-5f2b-aa7b-2ec5b1bd6602
DOI: 10.1101/141523

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