Dual role of the S5 segment in type 1 ryanodine receptor channel gating.

doi:10.1038/s42003-024-06787-1

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Article

Dual role of the S5 segment in type 1 ryanodine receptor channel gating.

Communications biology - 18 Sept 2024

Murayama Takashi, Otori Yuya, Kurebayashi Nagomi, Yamazawa Toshiko, Oyamada Hideto, Sakurai Takashi, Ogawa Haruo

Abstract excerpt

The type 1 ryanodine receptor (RyR1) is a Ca2+ release channel in the sarcoplasmic reticulum that is essential for skeletal muscle contraction. RyR1 forms a channel with six transmembrane segments, in which S5 is the fifth segment and is thought to contribute to pore formation. However, its role in channel gating remains unclear. Here, we performed a functional analysis of several disease-associated mutations in...

Topics

Ryanodine Receptor Calcium Release Channel
Ion Channel Gating
Humans
Mutation
HEK293 Cells
Animals
Calcium

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Identifiers

PMID: 39294299
DOI: 10.1038/s42003-024-06787-1
PMCID: PMC11411075

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