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Article

A conserved gating element in TRPV6 channels.

Cell calcium - 1 May 2017

Hofmann Laura, Wang Hongmei, Beck Andreas, Wissenbach Ulrich, Flockerzi Veit

Abstract excerpt

The Ca2+-selective tetrameric Transient Receptor Potential Vanilloid 6 (TRPV6) channel is an inwardly rectifying ion channel. The constitutive current endures Ca2+-induced inactivation as a result of the activation of phospholipase C followed depletion of phosphatidylinositol 4,5-bisphosphate, and calmodulin binding. Replacing a glycine residue within the cytosolic S4-S5 linker of the human TRPV6 protein, glycine...

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Source

Identifiers

PMID: 28029385
DOI: 10.1016/j.ceca.2016.10.003

Genes

TRPV6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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