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Article

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state.

Neuropharmacology - 1 Jun 2015

Zíma Vlastimil, Witschas Katja, Hynkova Anna, Zímová Lucie, Barvík Ivan, Vlachova Viktorie

Abstract excerpt

The ankyrin transient receptor potential channel TRPA1 is a polymodal sensor for noxious stimuli, and hence a promising target for treating chronic pain. This tetrameric six-transmembrane segment (S1-S6) channel can be activated by various pungent chemicals, such as allyl isothiocyanate or cinnamaldehyde, but also by intracellular Ca(2+) or depolarizing voltages. Within the S4-S5 linker of human TRPA1, a...

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Source

Identifiers

PMID: 25724085
DOI: 10.1016/j.neuropharm.2015.02.018

Genes

TRPA1
TRPV1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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