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Article

The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE".

PLoS medicine - 1 Dec 2016

Savas Peter, Teo Zhi Ling, Lefevre Christophe, Flensburg Christoffer, Caramia Franco, Alsop Kathryn, Mansour Mariam, Francis Prudence A, Thorne Heather A, Silva Maria Joao, Kanu Nnennaya, Dietzen Michelle, Rowan Andrew, Kschischo Maik, Fox Stephen, Bowtell David D, Dawson Sarah-Jane, Speed Terence P, Swanton Charles, Loi Sherene

Abstract excerpt

BACKGROUND: Understanding the cancer genome is seen as a key step in improving outcomes for cancer patients. Genomic assays are emerging as a possible avenue to personalised medicine in breast cancer. However, evolution of the cancer genome during the natural history of breast cancer is largely unknown, as is the profile of disease at death. We sought to study in detail these aspects of advanced breast cancers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28027312
DOI: 10.1371/journal.pmed.1002204
PMCID: PMC5189956

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