Article
Case report: 16-yr life history and genomic evolution of an ER+ HER2- breast cancer.
Cold Spring Harbor molecular case studies - 1 Dec 2020
Xu Bing, Amallraja Anu, Swaminathan Padmapriya, Elsey Rachel, Davis Christel, Theel Stephanie, Viet Sarah, Petersen Jason, Krie Amy, Davies Gareth, Williams Casey B, Ehli Erik, Meißner Tobias
Abstract excerpt
Metastatic breast cancer is one of the leading causes of cancer-related death in women. Limited studies have been done on the genomic evolution between primary and metastatic breast cancer. We reconstructed the genomic evolution through the 16-yr history of an ER+ HER2- breast cancer patient to investigate molecular mechanisms of disease relapse and treatment resistance after long-term exposure to hormonal...
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