The R213G polymorphism in SOD3 protects against allergic airway inflammation.

doi:10.1172/jci.insight.95072

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The R213G polymorphism in SOD3 protects against allergic airway inflammation.

JCI insight - 7 Sept 2017

Gaurav Rohit, Varasteh Jason T, Weaver Michael R, Jacobson Sean R, Hernandez-Lagunas Laura, Liu Qing, Nozik-Grayck Eva, Chu Hong Wei, Alam Rafeul, Nordestgaard Børge G, Kobylecki Camilla J, Afzal Shoaib, Chupp Geoffrey L, Bowler Russell P

Abstract excerpt

Oxidative stress is important in the pathogenesis of allergic asthma. Extracellular superoxide dismutase (EC-SOD; SOD3) is the major antioxidant in lungs, but its role in allergic asthma is unknown. Here we report that asthmatics have increased SOD3 transcript levels in sputum and that a single nucleotide polymorphism (SNP) in SOD3 (R213G; rs1799895) changes lung distribution of EC-SOD, and decreases likelihood...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchoalveolar Lavage Fluid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypersensitivity

Share to Interleukin-33

Share to Ovalbumin

Share to Porphyrins

Share to Respiratory Hypersensitivity

Share to Sputum

Share to Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 28878123
DOI: 10.1172/jci.insight.95072
PMCID: PMC5621928

Genes

SOD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The R213G polymorphism in SOD3 protects against allergic airway inflammation.PMID 28878123Read ↗

R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways.Semantic proximity Read ↗

Superoxide dismutases, lung function and bronchial responsiveness in a general population.Semantic proximity Read ↗

Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation.Semantic proximity Read ↗

SOD3 Variant, R213G, Altered SOD3 Function, Leading to ROS-Mediated Inflammation and Damage in Multiple Organs of Premature Aging Mice.Semantic proximity Read ↗

Genetic polymorphism of manganese superoxide dismutase is associated with childhood asthma.Semantic proximity Read ↗

Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways diseaseSemantic proximity Read ↗

Does SOD3 R213G Homozygosity Influence Morbidity, Mortality, and Lung Function in the General Population?Semantic proximity Read ↗

IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population.Semantic proximity Read ↗

A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology.Semantic proximity Read ↗

Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD.Semantic proximity Read ↗

MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways.Semantic proximity Read ↗

Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.