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Article

MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways.

Physiological genomics - 1 Jun 2020

Ohlstrom Denis, Hernandez-Lagunas Laura, Garcia Anastacia M, Allawzi Ayed, Karimpour-Fard Anis, Sucharov Carmen C, Nozik-Grayck Eva

Abstract excerpt

Oxidative stress is a key contributor to the development of dysregulated inflammation in acute lung injury (ALI). A naturally occurring single nucleotide polymorphism in the key extracellular antioxidant enzyme, extracellular superoxide dismutase (EC-SOD), results in an arginine to glycine substitution (R213G) that promotes resolution of inflammation and protection against bleomycin-induced ALI. Previously we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32421439
DOI: 10.1152/physiolgenomics.00116.2019
PMCID: PMC7311677

Genes

TREM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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