Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation.

doi:10.1165/rcmb.2016-0153OC

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Article

Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation.

American journal of respiratory cell and molecular biology - 1 Mar 2017

Mouradian Gary C, Gaurav Rohit, Pugliese Steve, El Kasmi Karim, Hartman Brittany, Hernandez-Lagunas Laura, Stenmark Kurt R, Bowler Russell P, Nozik-Grayck Eva

Abstract excerpt

Loss of extracellular superoxide dismutase 3 (SOD3) contributes to inflammatory and fibrotic lung diseases. The human SOD3 R213G polymorphism decreases matrix binding, redistributing SOD3 from the lung to extracellular fluids, and protects against LPS-induced alveolar inflammation. We used R213G mice expressing a naturally occurring single-nucleotide polymorphism, rs1799895, within the heparin-binding domain of...

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Identifiers

PMID: 27805412
DOI: 10.1165/rcmb.2016-0153OC
PMCID: PMC5359538

Genes

SOD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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