Article
Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD.
COPD - 1 Aug 2010
Sørheim I C, DeMeo D L, Washko G, Litonjua A, Sparrow D, Bowler R, Bakke P, Pillai S G, Coxson H O, Lomas D A, Silverman E K, Hersh C P
Abstract excerpt
Superoxide dismutase-3 (SOD3) is a major extracellular antioxidant enzyme, and previous studies have indicated a possible role of this gene in chronic obstructive pulmonary disease (COPD). We hypothesized that polymorphisms in the SOD3 gene would be associated with COPD and COPD-related phenotypes. We genotyped three SOD3 polymorphisms (rs8192287 (E1), rs8192288 (I1), and rs1799895 (R213G)) in a case-control...
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