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Does SOD3 R213G Homozygosity Influence Morbidity, Mortality, and Lung Function in the General Population?

Antioxidants & redox signaling - 20 May 2016

Kobylecki Camilla J, Afzal Shoaib, Nordestgaard Børge G

Abstract excerpt

The extracellular superoxide dismutase (SOD3, EC-SOD) enzyme is a major extracellular scavenger of the superoxide anion, a free radical with the potential to cause oxidative damage. Previously, R213G heterozygosity has been associated with a decreased risk of chronic obstructive pulmonary disease (COPD) and an increased risk of ischemic heart disease (IHD). We questioned whether SOD3 R213G homozygosity (213GG)...

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Identifiers

PMID: 26901385
DOI: 10.1089/ars.2016.6629

Genes

SOD3

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