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Article

R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways.

Physiological genomics - 1 Sept 2018

Garcia Anastacia M, Allawzi Ayed, Tatman Philip, Hernandez-Lagunas Laura, Swain Kalin, Mouradian Gary, Bowler Russell, Karimpour-Fard Anis, Sucharov Carmen C, Nozik-Grayck Eva

Abstract excerpt

Extracellular superoxide dismutase (EC-SOD), one of three mammalian SOD isoforms, is the sole extracellular enzymatic defense against superoxide. A known human single nucleotide polymorphism (SNP) in the matrix-binding domain of EC-SOD characterized by an arginine-to-glycine substitution at position 213 (R213G) redistributes EC-SOD from the matrix into extracellular fluids. We previously reported that knock-in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30004839
DOI: 10.1152/physiolgenomics.00053.2018
PMCID: PMC6172610

Genes

SOD3

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