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Article

Genetic polymorphism of manganese superoxide dismutase is associated with childhood asthma.

The Journal of asthma : official journal of the Association for the Care of Asthma - 1 Jun 2010

Kuo Chou Tsai-Nung, Li Ying-Shiuan, Lue Ko-Huang, Liao Che-Feng, Lin Chien-Yu, Tzeng Pei-Rung, Wong Ruey-Hong

Abstract excerpt

OBJECTIVE: Cellular defenses against allergens and reactive oxygen species (ROS) exposure are critical in the pathogenesis of asthma. CD14 is a receptor for various bacterial products, such as lipopolysaccharides (LPS), and is also a mediator of inflammatory processes. Manganese superoxide dismutase (MnSOD) is an ROS scavenger, and myeloperoxidase (MPO) can convert hydrogen peroxide into hypochlorous acid; thus,...

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PMID: 20536280
DOI: 10.3109/02770901003686472

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MPO

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