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Article

SOD3 Variant, R213G, Altered SOD3 Function, Leading to ROS-Mediated Inflammation and Damage in Multiple Organs of Premature Aging Mice.

Antioxidants & redox signaling - 20 Oct 2015

Kwon Myung-Ja, Lee Kyo-Young, Lee Han-Woong, Kim Jung-Ho, Kim Tae-Yoon

Abstract excerpt

AIMS: Among the isoforms of superoxide dismutase, SOD3 is uniquely associated with the extracellular matrix (ECM) by virtue of its heparin-binding domain (HBD). Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular...

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Source

Identifiers

PMID: 25927599
DOI: 10.1089/ars.2014.6035

Genes

SOD3
HBD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SOD3 Variant, R213G, Altered SOD3 Function, Leading to ROS-Mediated Inflammation and Damage in Multiple Organs of Premature Aging Mice.PMID 25927599Read ↗

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