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Article

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins.

Science signaling - 5 Sept 2017

White Katharine A, Ruiz Diego Garrido, Szpiech Zachary A, Strauli Nicolas B, Hernandez Ryan D, Jacobson Matthew P, Barber Diane L

Abstract excerpt

The intracellular pH (pHi) of most cancers is constitutively higher than that of normal cells and enhances proliferation and cell survival. We found that increased pHi enabled the tumorigenic behaviors caused by somatic arginine-to-histidine mutations, which are frequent in cancer and confer pH sensing not seen with wild-type proteins. Experimentally raising the pHi increased the activity of R776H mutant...

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Identifiers

PMID: 28874603
DOI: 10.1126/scisignal.aam9931
PMCID: PMC6022362

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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