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Article

pH sensing by FAK-His58 regulates focal adhesion remodeling.

The Journal of cell biology - 16 Sept 2013

Choi Chang-Hoon, Webb Bradley A, Chimenti Michael S, Jacobson Matthew P, Barber Diane L

Abstract excerpt

Intracellular pH (pHi) dynamics regulates diverse cellular processes, including remodeling of focal adhesions. We now report that focal adhesion kinase (FAK), a key regulator of focal adhesion remodeling, is a pH sensor responding to physiological changes in pH. The initial step in FAK activation is autophosphorylation of Tyr397, which increased with higher pHi. We used a genetically encoded biosensor to show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24043700
DOI: 10.1083/jcb.201302131
PMCID: PMC3776353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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