Article

Intracellular pH differentially regulates transcription of metabolic and signaling pathways in normal epithelial cells

2022-07-13

Abstract excerpt

<h4>Summary</h4> Intracellular pH (pHi) dynamics regulate normal cell function, and dysregulated pHi dynamics is an emerging hallmark of cancer (constitutively increased pHi) and neurodegeneration (constitutively decreased pHi). However, the molecular mechanisms by which pHi dynamics regulate cell biology are poorly understood. Here, we discovered that altering pHi in normal human breast epithelial cells triggers...

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Literature Corpus work: 62e11bad-d75a-538d-b0c6-7ff441057174
DOI: 10.1101/2022.07.12.499804

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