Article
pH and the Breast Cancer Recurrent Mutation D538G Affect the Process of Activation of Estrogen Receptor α.
Biochemistry - 15 Mar 2022
de Oliveira Vinícius M, Dias Marieli M G, Avelino Thayná M, Videira Natália B, da Silva Fernando B, Doratioto Tábata R, Whitford Paul C, Leite Vitor B P, Figueira Ana Carolina M
Abstract excerpt
Estrogen receptor α (ERα) is a regulatory protein that can access a set of distinct structural configurations. ERα undergoes extensive remodeling as it interacts with different agonists and antagonists, as well as transcription activation and repression factors. Moreover, breast cancer tumors resistant to hormone therapy have been associated with the imbalance between the active and inactive ERα states....
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