Article
Chromosome 5 allele loss in human colorectal carcinomas.
Nature - 1 Jan 2000
Solomon E, Voss R, Hall V, Bodmer W F, Jass J R, Jeffreys A J, Lucibello F C, Patel I, Rider S H
Abstract excerpt
That the sporadic and inherited forms of a particular cancer could both result from mutations in the same gene was first proposed by Knudson. He further proposed that these mutations act recessively at the cellular level, and that both copies of the gene must be lost for the cancer to develop. In sporadic cases both events occur somatically whereas in dominant familial cases susceptibility is inherited through a...
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