Article
Localization of the gene for familial adenomatous polyposis on chromosome 5.
Nature - 1 Jan 2000
Bodmer W F, Bailey C J, Bodmer J, Bussey H J, Ellis A, Gorman P, Lucibello F C, Murday V A, Rider S H, Scambler P
Abstract excerpt
Colorectal cancer is the second most common cancer in the United Kingdom and other developed countries in the West. Although it is usually not familial, there is a rare dominantly inherited susceptibility to colon cancer, familial adenomatous polyposis (FAP; also often previously called familial polyposis coli). During adolescence affected individuals develop from a few hundred to over a thousand adenomatous...
Topics
- Adenocarcinoma
- Adenomatous Polyposis Coli
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Colonic Neoplasms
- DNA
- DNA, Recombinant
- Gene Frequency
- Humans
- Mutation
- Nucleic Acid Hybridization