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Article

Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression.

Nature medicine - 1 Sept 1995

Boland C R, Sato J, Appelman H D, Bresalier R S, Feinberg A P

Abstract excerpt

Microallelotyping of many regions from individual colorectal tumours was used to determine the sequence and tempo of allelic loss on 5q, 17p and 18q during neoplastic progression. No allelic losses were found in normal tissues surrounding colorectal neoplasms, but losses occurred abruptly on 5q a...

Topics

Adenocarcinoma
Adenomatous Polyps
Alleles
Base Sequence
Cell Transformation, Neoplastic
Clone Cells
Colon
Colonic Polyps
Colorectal Neoplasms
Disease Progression
Epithelium
Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Polymerase Chain Reaction

Sequence Deletion

Source

Identifiers

PMID: 7585215
DOI: 10.1038/nm0995-902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7585215-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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