Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q.

Cancer genetics and cytogenetics - 1 Aug 1997

Frayling I M, Bodmer W F, Tomlinson I P

Abstract excerpt

The genes that are mutated in inherited cancer syndromes are often involved in the pathogenesis of sporadic cancers of the types that characterize those syndromes. In colorectal cancer such loci include the familial adenomatous polyposis (APC) gene and the hereditary nonpolyposis colorectal cancer (DNA mismatch repair) genes. Juvenile hamartomatous polyposis syndromes, which include Juvenile Polyposis and Cowden...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Alleles
Share to Chromosomes, Human, Pair 10

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to APC gene

Share to Gene Deletion

Source

Identifiers

PMID: 9242220
DOI: 10.1016/s0165-4608(97)00011-3

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q.PMID 9242220Read ↗

Juvenile polyposis and other intestinal polyposis syndromes with microdeletions of chromosome 10q22–23Semantic proximity Read ↗

Overlap of Juvenile polyposis syndrome and Cowden syndrome due to de novo chromosome 10 deletion involving BMPR1A and PTEN: implications for treatment and surveillance.Semantic proximity Read ↗

Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation.Semantic proximity Read ↗

Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locusSemantic proximity Read ↗

Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease.Semantic proximity Read ↗

Frequent alteration of the tumor suppressor gene APC in sporadic canine colorectal tumors.Semantic proximity Read ↗

Deletion 10q23.2-q23.33 in a patient with gastrointestinal juvenile polyposis and other features of a Cowden-like syndromeSemantic proximity Read ↗

Genome-wide allelotyping indicates increased loss of heterozygosity on 9p and 14q in early age of onset colorectal cancer.Semantic proximity Read ↗

Frequent loss of SMAD4/DPC4 protein in colorectal cancersSemantic proximity Read ↗

A new case with 10q23 interstitial deletion encompassing both PTEN and BMPR1A narrows the genetic region deleted in juvenile polyposis syndrome.Semantic proximity Read ↗

Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease.Semantic proximity Read ↗

Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.