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Article

Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology.

British journal of cancer - 1 Jun 1993

Cawkwell L, Bell S M, Lewis F A, Dixon M F, Taylor G R, Quirke P

Abstract excerpt

In order to investigate allele loss in colorectal tumours we have developed a rapid technique which overcomes most of the problems associated with radioactive Restriction Fragment Length Polymorphism (RFLP) analysis of allele loss. We utilise microsatellite length polymorphisms which are highly i...

Topics

Adenocarcinoma
Alleles
Chromosome Deletion
Chromosomes, Human, Pair 5
Colorectal Neoplasms
DNA, Neoplasm
Electrophoresis, Polyacrylamide Gel
Fluorescence
Humans
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 8512811
DOI: 10.1038/bjc.1993.236
PMCID: PMC1968523

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8512811-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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