Molecular nature of chromosome 5q loss in colorectal tumors and desmoids from patients with familial adenomatous polyposis.

doi:10.1007/BF00193581

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Article

Molecular nature of chromosome 5q loss in colorectal tumors and desmoids from patients with familial adenomatous polyposis.

Human genetics - 1 Oct 1990

Okamoto M, Sato C, Kohno Y, Mori T, Iwama T, Tonomura A, Miki Y, Utsunomiya J, Nakamura Y, White R

Abstract excerpt

Familial adenomatous polyposis (FAP), which includes familial polyposis coli (FPC) and the Gardner syndrome (GS), is a genetically determined premalignant disease of the colon inherited by a locus (APC) mapping within 5q15-q22. To elucidate the role of 5q loss in FAP tumorigenesis, we analysed 51...

Topics

Adenomatous Polyposis Coli
Alleles
Blotting, Southern
Chromosome Deletion
Chromosomes, Human, Pair 5
Colorectal Neoplasms
DNA Probes
Fibroma
Humans
Restriction Mapping

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