Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD.

Journal of the American Society of Nephrology : JASN - 1 Dec 2017

Udi Shiran, Hinden Liad, Earley Brian, Drori Adi, Reuveni Noa, Hadar Rivka, Cinar Resat, Nemirovski Alina, Tam Joseph

Abstract excerpt

Obesity-related structural and functional changes in the kidney develop early in the course of obesity and occur independently of hypertension, diabetes, and dyslipidemia. Activating the renal cannabinoid-1 receptor (CB1R) induces nephropathy, whereas CB1R blockade improves kidney function. Whether these effects are mediated via a specific cell type within the kidney remains unknown. Here, we show that specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Body Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Acids

Share to Fibrosis

Share to Kidney Failure, Chronic

Share to Kidney Tubules, Proximal

Share to Oxygen

Share to Receptor, Cannabinoid, CB1

Source

Open in PubMed Open full text

Identifiers

PMID: 28860163
DOI: 10.1681/ASN.2016101085
PMCID: PMC5698062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD.PMID 28860163Read ↗

Peripheral CB1R Blockade Suppresses AKI-to-CKD Maladaptive RepairSemantic proximity Read ↗

To CB2 or Not CB2: Revisiting Renoprotection in AKI and CKDSemantic proximity Read ↗

Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway.Semantic proximity Read ↗

Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans.Semantic proximity Read ↗

Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice.Semantic proximity Read ↗

Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes.Semantic proximity Read ↗

The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.Semantic proximity Read ↗

Loss of myeloid cannabinoid CB1 receptor confers atheroprotection by reducing macrophage proliferation and immunometabolic reprogrammingSemantic proximity Read ↗

Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 DiabetesSemantic proximity Read ↗

Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients.Semantic proximity Read ↗

Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene.Semantic proximity Read ↗

Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.