Article
Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients.
Metabolism: clinical and experimental - 1 Mar 2009
Sarzani Riccardo, Bordicchia Marica, Marcucci Pierfrancesco, Bedetta Samuele, Santini Silvia, Giovagnoli Andrea, Scappini Lorena, Minardi Daniele, Muzzonigro Giovanni, Dessì-Fulgheri Paolo, Rappelli Alessandro
Abstract excerpt
In overweight patients (OW), the increased peripheral activity of the endocannabinoid system in visceral adipose tissue (VAT) may be mediated by cannabinoid type 1 (CB1) receptor expression. We determined whether CB1 receptor splice variants and messenger RNA (mRNA) levels in perirenal and subcutaneous adipose tissues are associated with obesity and metabolic syndrome (MetS). Gene expression with multiple-primers...
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