Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes

12 Jan 2017

Abstract excerpt

Islet inflammation promotes β-cell loss and type 2 diabetes (T2D), a process replicated in Zucker Diabetic Fatty (ZDF) rats in which β-cell loss has been linked to cannabinoid-1 receptor (CB1R)–induced proinflammatory signaling in macrophages infiltrating pancreatic islets. Here, we analyzed CB1R signaling in macrophages and its developmental role in T2D. ZDF rats with global deletion of CB1R are protected from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cannabis and Cannabinoid Research
Share to Diet, Metabolism, and Disease
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28082458
DOI: 10.2337/db16-1199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 DiabetesPMID 28082458Read ↗

Loss of myeloid cannabinoid CB1 receptor confers atheroprotection by reducing macrophage proliferation and immunometabolic reprogrammingSemantic proximity Read ↗

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.Semantic proximity Read ↗

Formation of B and T cell subsets require the cannabinoid receptor CB2.Semantic proximity Read ↗

Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner.Semantic proximity Read ↗

Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and diseaseSemantic proximity Read ↗

Macrophage Contact Dependent and Independent TLR4 Mechanisms Induce β-Cell Dysfunction and Apoptosis in a Mouse Model of Type 2 DiabetesSemantic proximity Read ↗

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice.Semantic proximity Read ↗

Minireview: Emerging Concepts in Islet Macrophage Biology in Type 2 DiabetesSemantic proximity Read ↗

Expression of the Type I Diabetes-associated Gene LRP5 in Macrophages, Vitamin A System Cells, and the Islets of Langerhans Suggests Multiple Potential Roles in DiabetesSemantic proximity Read ↗

Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus.Semantic proximity Read ↗

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.Semantic proximity Read ↗

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.