Article
Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway.
The Journal of biological chemistry - 16 Sept 2005
Jiang Tao, Wang Zhuowei, Proctor Gregory, Moskowitz Shevie, Liebman Scott E, Rogers Thomas, Lucia M Scott, Li Jinping, Levi Moshe
Abstract excerpt
Obesity and metabolic syndrome are associated with glomerulosclerosis and proteinuria, but the mechanisms are not known. The purpose of this study was to determine if there is altered renal lipid metabolism and increased expression of sterol regulatory element-binding proteins (SREBPs) in a model of diet-induced obesity. C57BL/6J mice that were fed a high fat, 60 kcal % saturated (lard) fat diet (HFD) developed...
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