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Article

Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer's disease mouse model.

Scientific reports - 13 Feb 2017

Criscuolo Chiara, Fontebasso Veronica, Middei Silvia, Stazi Martina, Ammassari-Teule Martine, Yan Shirley ShiDu, Origlia Nicola

Abstract excerpt

The Entorhinal cortex (EC) has been implicated in the early stages of Alzheimer's disease (AD). In particular, spreading of neuronal dysfunction within the EC-Hippocampal network has been suggested. We have investigated the time course of EC dysfunction in the AD mouse model carrying human mutation of amyloid precursor protein (mhAPP) expressing human Aβ. We found that in mhAPP mice plasticity impairment is first...

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Identifiers

PMID: 28205565
DOI: 10.1038/srep42370
PMCID: PMC5304222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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