Article

Sequence Determinants of Human Junctophilin-2 Protein Nuclear Localization and Phase Separation

2021-05-18

Abstract excerpt

Junctophilin-2 (JPH2) was conventionally considered as a structural membrane binding protein. Recently, it was shown that proteolytically truncated mouse JPH2 variants are imported into nucleus to exert alternative functions. However, the intranuclear behaviors of human JPH2 (hJPH2) and underlying molecular determinants have not been explored. Here, we demonstrate that full-length hJPH2 is imported into nucleus in...

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Literature Corpus work: f8c838c3-8b75-54ab-829d-823117fb9545
DOI: 10.1101/2021.05.17.444513

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