Article

Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4

2023-09-29

Abstract excerpt

Highly homologous ubiquitin-binding shuttle proteins UBQLN1, UBQLN2 and UBQLN4 differ in both their specific protein quality control functions and their propensities to localize to stress-induced condensates, cellular aggregates and aggresomes. We previously showed that UBQLN2 phase separates in vitro , and that the phase separation propensities of UBQLN2 deletion constructs correlate with their ability to form c...

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Literature Corpus work: 1202cedf-4fab-549e-ad83-c85b6b671822
DOI: 10.1101/2023.09.27.559790

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