Lung Endothelial MicroRNA-1 Regulates Tumor Growth and Angiogenesis

Abstract excerpt

RATIONALE: Vascular endothelial growth factor down-regulates microRNA-1 (miR-1) in the lung endothelium, and endothelial cells play a critical role in tumor progression and angiogenesis. OBJECTIVES: To examine the clinical significance of miR-1 in non-small cell lung cancer (NSCLC) and its specific role in tumor endothelium. METHODS: (KP) mice, lung-specific vascular endothelial growth factor transgenic mice,...

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