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Article

Loss of miR125a expression in a model of K-ras-dependent pulmonary premalignancy.

Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2014

Liclican Elvira L, Walser Tonya C, Hazra Saswati, Krysan Kostyantyn, Park Stacy J, Pagano Paul C, Gardner Brian K, Larsen Jill E, Minna John D, Dubinett Steven M

Abstract excerpt

Understanding the molecular pathogenesis of lung cancer is necessary to identify biomarkers/targets specific to individual airway molecular profiles and to identify options for targeted chemoprevention. Herein, we identify mechanisms by which loss of microRNA (miRNA)125a-3p (miR125a) contributes to the malignant potential of human bronchial epithelial cells (HBEC) harboring an activating point mutation of the...

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Identifiers

PMID: 24913817
DOI: 10.1158/1940-6207.CAPR-14-0063
PMCID: PMC4125465

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CXCL1

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