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Article

Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions.

Oncotarget - 15 Sept 2015

Pedrosa Ana-Rita, Trindade Alexandre, Carvalho Catarina, Graça José, Carvalho Sandra, Peleteiro Maria C, Adams Ralf H, Duarte António

Abstract excerpt

Angiogenesis is an essential process required for tumor growth and progression. The Notch signaling pathway has been identified as a key regulator of the neo-angiogenic process. Jagged-1 (Jag1) is a Notch ligand required for embryonic and retinal vascular development, which direct contribution to the regulation of tumor angiogenesis remains to be fully characterized. The current study addresses the role of...

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Source

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Identifiers

PMID: 26213336
DOI: 10.18632/oncotarget.4380
PMCID: PMC4695194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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